Anal cancers are predominantly preceded by screening-detectable high-grade squamous intraepithelial lesions (HSILs). Despite being relatively uncommon in the general population, possessing an incidence rate of 1.7 per 100,000 person-years, anal cancers disproportionately affects specific groups of individuals, particularly people with human immunodeficiency virus (HIV), solid organ transplant recipients and women with a history of vulvar cancer or precancer.

Anal cancers are predominantly preceded by screening-detectable high-grade squamous intraepithelial lesions (HSILs). Despite being relatively uncommon in the general population, possessing an incidence rate of 1.7 per 100,000 person-years, anal cancers disproportionately affects specific groups of individuals, particularly people with human immunodeficiency virus (HIV), solid organ transplant recipients and women with a history of vulvar cancer or precancer.

Multisystem inflammatory syndrome in children (MIS-C) is a novel post-infectious inflammatory condition associated with Coronavirus disease 2019 (COVID-19), characterized by prolonged fever, gastrointestinal (GI) symptoms and rash. To some extent, the disease resembles Kawasaki disease (KD), toxic shock syndrome (TSS), and hemophagocytic lymphohistiocytosis (HLH), increasing the difficulty in differential diagnosis in clinical practice. In an interview with Omnihealth Practice, Dr. Cheung, Wai-Yin Eddie discussed the challenge of evaluating suspected MIS-C cases in real-life scenarios and emphasized the importance of timely intervention among children who were infected with or recently recovered from COVID-19. He also shared a clinical case of a 7-year-old girl with MIS-C who presented with early MIS-C symptoms and was managed with immunomodulatory treatment, swiftly achieving favorable outcomes.

With up to 6 months of follow-up in an ongoing, placebo-controlled, observer-blinded, multinational, pivotal efficacy study, the 6-month safety and efficacy data of BNT162b2 mRNA COVID-19 have been updated and summarized in this report. The current outbreak of the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) discovered in January 2020, has spread to countries around the world with recent estimates of more than 200 million cases diagnosed and over 4 million deaths. Coronaviruses are enveloped, positive-sense single‐stranded ribonucleic acid (RNA) viruses, and SARS-CoV-2 belongs to the B lineage of the beta-coronaviruses. The predominant clinical manifestations of SARS-CoV-2 include fever, cough, and other symptoms and signs of respiratory tract infections.