Tag : ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

A reduction in LDL-C is associated with improvements in CV outcomes in patients with ASCVD.1 As such, multiple guidelines recommend LDL-C targets of <55mg/dL and <70mg/dL based on baseline risks. However, many patients fail their LDL-C goals due to clinical inertia, medication nonadherence, side effects, and/or poor healthcare access. Inclisiran is a first-in-class siRNA that inhibits hepatic PCSK9 production and increases LDL receptor expression and LDL-C clearance. In clinical studies, twice-yearly administration of inclisiran has been shown to achieve a 50% reduction in LDL-C.