Tag : PSORIASIS
A retrospective cohort study found that psoriasis patients aged 55 and older had a higher risk of age-related macular degeneration (AMD) compared to matched controls, suggesting the need for vigilant screening for ocular comorbidities in psoriasis management and the potential impact of lipid dysregulation on AMD progression.
Guselkumab showed promising results in achieving significant scalp skin clearance among Chinese patients with moderate-to-severe psoriasis, as highlighted in a phase 4 study analysis. In this analysis, super responders (PASI 100) tended to be younger, had lower body weight, and had no prior use of non-biologic systemic therapy.
Psoriasis is a chronic inflammatory disorder characterized by systemic inflammation and elevated circulating levels of pro-inflammatory cytokines. This persistent inflammatory state has been implicated in immune-mediated injury across multiple organ systems, with particular involvement of renal tissues. However, few large-scale studies have evaluated whether psoriasis independently increases the risk of renal complications in type 2 diabetes mellitus (T2DM) patients receiving guideline-directed renoprotective therapies. A retrospective cohort study was performed by researchers in Texas to compare the risk of diabetic nephropathy, chronic kidney disease (CKD), end-stage renal disease (ESRD), and dialysis in T2DM patients with and without psoriasis who were receiving angiotensin-converting enzyme inhibitor (ACEI), angiotensin II receptor blocker (ARB) or sodium-glucose cotransporter-2 inhibitor (SGLT2i) therapies.
Limited treatment options are currently available for psoriasis, including topical corticosteroids, oral anti-inflammatory medications, biologic therapies, and phototherapy. Phototherapy is a cost-effective alternative that has demonstrated excellent efficacy and safety, leading to better patient-reported outcomes. Phototherapy also improves cardiovascular biomarkers and does not carry a risk of infection. While a survey of more than 2,500 psoriasis patients and 1,000 dermatologists across the United States revealed that phototherapy remains a preferred treatment option, particularly for home phototherapy among patients, barriers such as inconvenience, accessibility, and insufficient insurance coverage hinder its use.
