Tag : RAVULIZUMAB

  • CONFERENCE UPDATE
    Ravulizumab shows sustained efficacy and safety in preventing relapses in AQP4+ NMOSD: Interim results from the CHAMPION-NMOSD trial

    Aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+ NMOSD) is a rare autoimmune disease of the central nervous system characterized by recurrent and unpredictable relapses, which can lead to significant and irreversible neurological disability. Ravulizumab is a long-acting C5 complement inhibitor designed to prevent relapses in patients with AQP4+ NMOSD. This interim analysis presents long-term outcomes from the CHAMPION-NMOSD study, evaluating the efficacy and safety of ravulizumab in adults with AQP4+ NMOSD over a median follow-up period of 170.3 weeks.

  • CONFERENCE UPDATE
    Final results from CHAMPION MG OLE demonstrated the long-term efficacy and safety of ravulizumab in adults with AChRAb+ gMG

    Autoantibodies against the acetylcholine receptor (AChR) are often found in patients with generalized myasthenia gravis (gMG), which destroy the post-synaptic membrane of the neuromuscular junction (NMJ) via aberrant complement cascade activation. Humanized monoclonal antibodies with a high affinity to the human terminal complement component C5 such as ravulizumab inhibit the membrane attack complex formation. Previously, the 26-week randomized controlled period (RCP) of the phase 3 CHAMPION MG study demonstrated the efficacy and safety profile of ravulizumab in adult patients with anti-acetylcholine receptor antibody-positive (AChRAb+) gMG.