Tag : SELECTIVE SEROTONIN REUPTAKE INHIBITORS

  • RESEARCH SPOTLIGHT
    Overcome the flat dose-response of ssri with venlafaxine

    This study provided evidence of the possible existence of a dose-response relationship with venlafaxine. Depression is a major contributor to disability, affecting 322 million people or 4.4% of the world’s population.1 Its prevalence has been increasing over the years by an estimated 18% between 2005 and 2015. The management of depression includes non-pharmacological options such as psychotherapy or pharmacological options, mainly the second-generation antidepressants such as first-line serotonin reuptake inhibitors (SSRIs).

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    Lancet Psychiatry. 2019

    Furukawa TA, et al. Optimal dose of selective serotonin reuptake inhibitors (SSRIs), venlafaxine, and mirtazapine in major depression: A systematic review and dose-response meta-analysis.