Tag : STATIN INTOLERANCE

Bempedoic acid inhibits ATP citrate lyase, an enzyme upstream of 3-hydroxy-3-methalglutaryl-coenzyme (HMG-CoA) reductase which is the rate-limiting step of cholesterol biosynthesis. This reduces hepatic cholesterol synthesis and raises LDL receptor expression, increasing the clearance of LDL-C from the circulation.